The prevalence of diabetes in pregnancy is rising in all maternal age groups. There is increasing evidence that in-utero exposure to maternal diabetes is associated with an increased risk of obesity and type 2 diabetes in children and adults. There is an urgent need to reduce these increasing rates of obesity and diabetes in subsequent generations.
The MiTy trial (Metformin in Women with Type 2 Diabetes in Pregnancy Trial) is a CIHR-funded multi-centre, randomized controlled trial of women with type 2 diabetes in pregnancy (sample size n=500). The MiTy trial is looking to determine the effect of the addition of metformin to a standard regimen of insulin in women with diabetes, on perinatal morbidity and mortality.
The MiTy Kids trial is a follow-up to the MiTy trial which will determine whether treatment with metformin during pregnancy, in women with type 2 diabetes will lead to a reduction in adiposity and improvement in insulin resistance, in the offspring of women with diabetes at 2 years of age.
E-mail MiTyKids@sunnybrook.ca for more information.